Practical optimization: where to start

Run your program on a platform slow enough that you

1. care, and
2. can feel where the problems are.

(Something — I assume a Chrome update — caused Cubes to run more slowly. Over fifteen seconds of startup time is just not fun for debugging, so I went looking for problems. Unfortunately, it wasn't anything straightforwardly bad, but the heaviest thing in the profile was the color-picking while constructing the default blockset, so I optimized that and got the startup down to about six seconds. Still slower than it really ought to be.)